Methylmalonic acidemia (MMA) is a genetic disorder that makes the body unable to digest certain proteins and fats. The undigested substance releases methylmalonic acid into the bloodstream. These toxin chemicals in the blood can result in some consequential illnesses in the patients. However, this genetic metabolism disorder transfers from parent to infant.
Here are some risk factors associated with this inborn error of metabolism.
- Family history: Since it is an inborn metabolism disorder, it passes to the child from the parents through genes. If one of the parents has Methylmalonic academia, then there are chances the next generation will inherit it.
- Genetic mutation: The deficiency of methyl malonyl CoA mutase and defects in the synthesis of the coenzyme adenosylcobalamin results in changes in genetic encoding; thus, it develops methylmalonic acidemia.
- Age: This disorder is more prone in infants and young age children. Unfortunately, in some cases, the child dies before being diagnosed.
- High protein diet: This disorder triggers food items high in proteins and fats. A person with MMA can’t digest protein-like building blocks, amino acids and lipids fats. Thus, consuming such elements in the body will worsen the patient's condition.
- Pregnancy: the child is more likely to inherit the genes leading to MMA.
The body can’t digest certain fats and proteins,Formation of hazardous chemicals in the bloodstream,Affect the kidneys and liver,Restrain the patient from growth and result in weaker immunity
Cobalamin (vitamin B12) given as an injection,Carnitine,Antibiotics
Lethargy,Improper growth,Diminished muscle tone, Recurrent vomiting,Dehydration,Respiratory distress,Acidosis,Weaker immunity