Acrodermatitis enteropathica (AE) is a disorder of zinc metabolism that occurs in one of two forms: an inborn (congenital) form and an acquired form. The inborn form of AE is a rare genetic disorder characterized by intestinal abnormalities that lead to the inability to absorb zinc from the intestine. The lack of zinc presents, characteristically, as: (1) skin inflammation with pimples (pustular dermatitis) occurring around the mouth and/or an  Read More

Congenital zinc deficiency is an inborn error mechanism in thezinc availability in the body. Although dietary variables are frequently the cause of zinc deficiency, various genetic abnormalities of zinc insufficiency have been reported. The most frequently reported inherited human ailment is acrodermatitis enteropathica. In several of the few cases that have been reported, this disorder is associated with mutations in the hZIP4 gene, a member o  Read More