GALT generally refers to a gene responsible for producing an enzyme called galactose-1-phosphate uridylyltransferase. It is one such enzyme that is responsible for processing galactose in foods that are consumed in a small amount.
Deficiency of these GALT enzymes leads to Galactosemia/GALT deficiency, a situation that disrupts the GALT gene, eventually resulting in the accumulation of galactose chemicals in different organs of the human body, diagnosed in 1 in 30,000 newborns every year.
Below are the risk factors associated with GALT deficiency:
- Untreated Galt deficiency can result in blood infection, leading to death.
- Brain damage is another risk factor associated with Galactosemia.
- Some infants might also develop cataracts and liver disease when untreated with precautionary measures.
- When newborns are fed milk while suffering from gallbladder disease, they may experience irritability, vomiting, jaundice, and lethargy.
- Speech problems
- Intellectual disabilities are observed to result in delays in learning.
- unsteady gait observed at an early age.
Hereditarily, the GALT deficiency in babies arises in two conditions:
- A child inherits one non-working GALT gene from each parent.
- Inheriting the gene from both parents, who are the carriers. In this case, the child has a 50% chance of serving as a carrier.
Hepatomegaly is a condition of liver enlargement,Decrease in blood sugar level,Presence of amino acids in urine,Accumulation of galactose in other parts of the body
There is no medication for GALT deficiency, however, a low-galactose diet can add to its precaution to some extent
Cataracts in infants,Delay in growth and development,Intellectual disability,Kidney and liver problems